What do you mean by "create"?

Nothing is created, nothing is lost, everything can be transformed.

But the transformation possibilities are limited by conservation laws: electric charge, mass-energy, linear momentum, baryonic number, leptonic number ...

The consequence is that you cannot create an electron (a negative lepton) without destroying another lepton (and even so the conservation of energy and momentum implies that other particles must be involved in the process) or creating simultaneously a positive antilepton (the positron). The same is true for the proton (positive baryon) and the neutron (neutral baryon): another baryon must be destroyed, or you have to create a baryon/antibaryon pair.