Recently, researchers have been looking for a optimum combination of chemicals to boost up the anticancer potential of certain chemical compounds. May be to overcome the resistance to of some drugs like cisplatin, 5FU etc. I am curious to know the updates regarding this type of research outcomes. Thank you!!!
Almost all the standard protocols for cancer treatment use combined chemotherapy. You can find them in any updated textbook of oncology. The big problem usually starts when first and second line protocols are not working anymore due to cancer cell resistance. This is the point where we need new approaches. The standard treatments at this stage show very poor results. We have some experimental evidence with very advanced cancer patients that targeting tumor pH is capable of producing stable disease for extended time.
A totally agree with Dr. Tomas Koltai. We also perform synergistic experiments of several different classes of compounds, such as Hsp90 inhibitors or pH modulators combined with well known anticancer drugs. If compound itself is not relatively very toxic and it could enhance the activity of anticancer drugs, it is generally considered as a rational way to improve the treatment, and sometimes it could help to prevent from resistance to chemotherapy.
Thank you Dr. Tomas and Dr. Vilma for excellent answers. I am really interested in this regrads.
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