I am planing to detect breast cancer by some electrochemical means and for that I have to select some bio-markers.
itis one of the tyrosnie kinases overexpressed in breast cancer and associated with poor prognosis
(Ki67, ER alpha, ErbB2, p53, PgR
ErbB2 is a member of the human epidermal growth factor receptor (HER/EGFR/ERBB) family. Amplification or overexpression of this oncogene has been shown to play an important role in the development and progression of certain aggressive types of breast cancer
As indicated by the other comments, ErbB2 is a common marker for certain types of breast cancer. Concerning prognosis and response to therapy, the worst forms of breast cancer are the ones lacking the common markers.
Depending on the type of breast cancer, there are several biomarkers you can use. Mutant p53, mutant PI3K for triple negative breast cancer. HER2 for HER2- positive breast cancer. CyclinD1, and Ki67 overexpression for Luminal positive breast cancer.
in terms of biomarkers with validated clinical utility, the established triplet would be ER/PgR/ErbB2 (HER2). All three bear both prognostic and predictive relevance, since:
- the first two hormone receptors are associated with positive prognostication and predict for benefit derived from endocrine treatment
- erbB2 (HER2) is a marker of poor prognosis and is associated with prediction of benefit from HER2 blocking agents (4 such agents approved in the setting of breast cancer: trastuzumab, pertuzumab, lapatinib and TDM1).
Ki67 has also prognostic relevance (higher proliferation rates associated with aggressiveness of the disease) and some predictive relevance, since higher Ki67 levels have been associated with chemosensitivity.
Best
- Badges
- Science topic
- Similar topics
- Chemistry
- Electrochemistry