H, try reading this articule even though the sample is smoll: Radical treatment of cancer and its metastases with innocuous therapy at the cellular level.

Dear Yaying Pan

Combining immunotherapy with chemotherapy has shown significant promise in many clinical trials, leading to improved outcomes for various cancers. This combination approach enhances the immune system's ability to fight cancer by exposing more antigens and modulating the tumor microenvironment to be more receptive to immune attacks. This combination can increase overall survival rates compared to chemotherapy alone, particularly in advanced stages of certain cancers.

Accordingly, many clinical trials combining PD-1/PD-L1 blockade with chemotherapy have already been completed, and several chemo-immunotherapy combinations have recently been clinically approved owing to their improvement in patient survival, with generally expected safety profiles of known toxicities.

While the combination shows promise, ongoing research continues to explore the optimal dosing, timing, and sequencing of these treatments, as well as their effectiveness in various cancer types.

Attached below are a few references.

Article Atezolizumab in combination with carboplatin plus nab-paclit...

Article Pembrolizumab plus Chemotherapy in Metastatic Non–Small-Cell...

https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.940567/full

Article Systematic Analysis of Chemotherapy, Immunotherapy, and Comb...

https://www.dovepress.com/immunotherapy-in-combination-with-well-established-treatment-strategie-peer-reviewed-fulltext-article-CMAR

https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1477980/full

Regards,

Malcolm Nobre