Hello everyone,

I am currently exploring several options to give the collected data the greatest value possible.

I have demographic data on older people, where I perform various memory and mood tests. The previous hypotheses were the following:

  • Drawing out the difference between dementia and depression.
  • Identify if the digital tool is as effective as the classic one
  • Contributing to the data collected as a predictor of dementia

A few years ago, studies talked about the real possibility of predicting some years before, what your future mental health will be in terms of memory.

Do you think there is any way to provide value in that sense, with demographic data, clinical tests like MoCa, Yesavage, Lawton, MFE?

Here you are some of these studies.

Study of the brain through images:

  • Jagust, W. (2018). Images of the evolution and pathophysiology of Alzheimer's disease. Nature Reviews. Neuroscience, 19(11), 687–700. doi:10.1038/s41583-018-0067-3.

Analysis of biomarkers in cerebrospinal fluid or blood:

  • Hampel, H., O'Bryant, S. E., Castrillo, J. I., Ritchie, C., Rojkova, K., Broich, K.,… Lista, S. (2018). PRECISION MEDICINE – The golden door for the detection, treatment and prevention of Alzheimer's disease. Journal of Alzheimer's Disease Prevention, 5(4), 243–259. doi:10.14283/jpad.2018.29.

Genetic studies:

  • Karch, C. M., and Goate, A. M. (2015). Alzheimer's disease risk genes and mechanisms of disease pathogenesis. Biological Psychiatry, 77 (1), 43–51. doi:10.1016/j.biopsych.2014.05.006.

Cognitive evaluations and neuropsychological tests:

  • Amariglio, R. E., Becker, J. A., Carmasin, J., Wadsworth, L. P., Lorius, N., Sullivan, C.,… Sperling, R. A. (2012). Subjective cognitive complaints and amyloid burden in cognitively normal older people. Neuropsychology, 50(12), 2880–2886. doi:10.1016/j.neuropsychologia.2012.08.011.

With python and with sk-learn is a best way to start?

Which features are the more relevants to add value to the prediction?

Thanks in advance,

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