What could be the factors like ROS, different cytokines, platelet derived growth factors etc which can actually induce the hypersecretion of insulin or insulin-like growth factors in the blood?
Thanks for your reply. The attached paper is good and interesting. But I am actually looking at more molecular basis which leads to insulin and IGF overexpression and underexpression.......... Defined molecular basis which induced pancreatic beta cells to release insulin and IGF (also from other cells) other than serum free glucose concentration.