Dear all,
Among different types of enzymes, what are the most frequently studied classes of enzymes closely linked with colorectal cancer? Please suggest some enzyme inhibitors based on in vitro and in silico studies. Thank You.
Vascular endothelial growth factor (VEGF) is a protein that helps tumors form new blood vessels to get nutrients (a process known as angiogenesis). Drugs that target EGFR can be used to treat some advanced colon or rectal cancers. These include:; Bevacizumab (Avastin), Ramucirumab (Cyramza), Ziv-aflibercept (Zaltrap).
Epidermal growth factor receptor (EGFR) also is a protein that often appears in high amounts on the surface of cancer cells and helps them grow. Drugs that target EGFR can be used to treat some advanced colon or rectal cancers. These include; Cetuximab (Erbitux) , Panitumumab (Vectibix)
Additionally, Regorafenib (Stivarga) is a type of targeted therapy known as a kinase inhibitor.
Selleckchem.com has provided different class of inhibitors for screening.
Thymidylate synthetase and tyrosine kinase this two enzyme can be the good target for colon cancer.
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