It was known that pyrithroid insecticide were effective and more safer than organo-phosphorous insecticides. But recently some studies reported that mosquitos in some part of the world get resistance to pyrithroid preparations, so how can we find other insecticide to avoid organophosphates usage? is it possible to modify the existing pyrithroids chemical structure to potentiate their efficacy without increasing their drawbacks?.
In fact, we have reduce dependency on the use of chemicals. Pesticides have long term effect on ecology.Therefore, it is necessary to adopt and practice biological control of harmful insects for safer world. More research is required to address this issue. Preventive control of these type of insects is desirable.However, limited use of pesticides can be effective in extreme cases.
Please indicate the studies that reported mosquitoes in some parts of the world get resistance to pyrithroid preparations.
Of course, it is possible to modify existing pyrithroid chemical structure. Because of the limitations of Organo-Chlorine, Orogano-Phosphorous was evolved. Pyrithroid was developed as it was considered more safer the Organo-Phosphorous. Please make your efforts to develop more safer echo-friendly pesticides.
Tanks a lot for your response and your valuable comments and thoughts. For biological control, which is sounds very promising I think this process needs more efforts to be applicable. But when raised the question about Pyrithroids because they found many applications, specially in the in door spraying and in impregnation of bed nets, so their daily use mandate to find some insecticides having better effects and of low side effects. Here I am seeking for those who are interested in this field, maybe we can make a group of interested people to search for new approaches for chemical modification of Pyrithroids or to search for any safest compounds to face the resistance problem.
Dear colleague,
It has been reported that masquito species exhibited resistance (metabolic and target-sites) to the fourth classes of insecticides widely used (OC, OP, carbamates, pyrethroids), They are some selective insecticides such as inscet growth disruptors (IGDs). You must use these products by alternance in order to reduce the process of resistance. In the attached documents you find a list of products used against adults and larvae and also the efficacy of some IGDs tested in our laboratory against Culex pipiens with their references.
Good luck !
Pr. N. Soltani
Dear colleague,
Thank you very much for your valuable information enclosed in the attachment. Maybe I will refer to you for some researches in this area
Thanks a lot
Dear Ahmed, to overcome metabolic pyrethroid resistance in mosquitos you can apply a pyrethroid together with piperonyl butoxide (PBO) which acts like a resistance breaker, due to its inhibition of the detoxifying cytochrome P450 enzymes (often monooxygenases). You can find multiple examples in the literature.
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