I have encountered many organic reactions where I had taken 2 reactants in the molar ratio of 1:2, 1:1.5 etc but after a while TLC examination showed that the limiting reactant(which has been taken as 1 equivalent) is still present on the TLC plate even though a new spot is formed.What are the various ways to totally consume that reactant completely?
I have tried various ways to solve this issue like increasing the molar ratio by taking more no of equivalents of the other reactant, waiting for a longer period of time hoping for the reaction to complete and also heating the reaction.I have been successful using these strategies, but only very rarely.
Are there any other ways to address this issue?
sorry about the previous reply and forget it. I just read the detailed of your problem. It always happen to us, especially for some reactions, if there are water or halogen hydride generated in situ, just remove or locked it timely. or maybe your conditions such as solvents are not the best, or sometimes you can have a try of microwave. I always just recycle the start materials if the product is enough for next. of course, if you focus on process study, you'd better solve it and good luck!
It is possible to use the non-limiting reactant as solvent ?
If water is formed, try to use a Dean-Stark system.
If you are using organomets coumpounds, the flask have to be completely dry (anhydrous)...
We need more data to answer...
It is a reaction between 2 solid reactants and 1 solid catalyst where i am using a solvent and heating it
What kind of reaction is it (nucleophilic substitution, coupling reaction...) ??? Try another solvent (most common used organic solvents, ionic liquids,...) and/or another catalyst
substitution reaction. I am using halogenated solvents which have high boiling point.
Since you said you use a catalyst, have you tried to increase the catalyst loading to maximize your turn over? At least in this particular scenario, it is likely that your catalyst is getting "consumed," which in turn affects the conversion.
I understand you are not in a position to divulge your chemistry, but maybe you could divulge a wee bit as people are clearly showing interest in helping you. I am afraid beating about the bush isn't going to help anyone's cause.
I think increasing the catalyst loading may help. I have to try that out
Hi, Peter
I would not be surprised if you disclose all intricate details of your current project in a conference or seminar .You would clearly see the game then.
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