Please share your/others experiences/findings related to PCOS in rodents.
I refer you to this article: https://www.ikprress.org/index.php/JOBI/article/view/3472
I think this article is useful to you. Animal models of polycystic ovary syndrome: A review of horm...
The following article is a detailed overview of your query. Kindly read it
Shi D, Vine DF. Animal models of polycystic ovary syndrome: a focused review of rodent models in relationship to clinical phenotypes and cardiometabolic risk. Fertility and sterility. 2012 Jul 1;98(1):185-93.
You may find one of the most comprehensive reviews of different animal models of PCOS here:
https://doi.org/10.1210/endrev/bnaa010
There are several types of Rodent PCOS models. Pros and cons have extensively discussed in the review. Depending on the features you want to assess there are few distinct options. Overall, both post and prenatal hyperandrogenzed models are the most reliable ones. Our research has showed that postnatal DHT model is one the robust models of PCOS replicating a broad range of PCOS features in rodents. Prenatal T models are another option which have shown promising results.
Hope you find this helpful.
- Badges
- Science topic
- Similar topics
- Social Science
- Media
- Journalism