What are the differences between SV40 early and late polyA signals?

Lu Wei @Lu-Wei-12

14 September 2018 1 6K Report

Any differences especially on biological functions?

How to select between these two when you try to establish an expression vector or some reporter systems?

Thank you all!

Lu Wei

sequence difference, partial reverse complemented with each other.

It is reported that SV40 late PAS is more efficient to terminate transcription than SV40 early PAS. Two potential useful papers:

1. THE JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 278, No. 43, Issue of October 24, pp. 41691–41701, 2003

2. MOLECULAR AND CELLULAR BIOLOGY, Jan. 1998, p. 276–289

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