Its depends on your need , most of the literature says that for the expression of IL-beta, you have to choose J 774.1,its due to the activation of inflammasome component ASC+, it will give good results but when it with RAW 264.7 will not get any or limited expression of IL-beta, then its very difficult for you to get well Blots for IL-beta

and

for maintenance or seeding the cells J 744.1 need more number of cells when compared with RAW 246.7 because of high cell -cell interactions between cells for propagation.