Can somebody tell me the rules or checkpoints while selecting drug targets (from Mycobacterium tuberculosis H37Rv)for in silico Structure Based Drug Discovery study?
In my opinion one point is ..
1. There should not be any human homologs while selecting targets.
I invite suggestions from my friends n experts....
The target should be essential for survival of the mycobacteria. Particularly valuable would be targets that are essential for persistence of non-replicating mycobacteria. You must have a high-quality x-ray crystal structure, of course. It would also be helpful to have structures with ligands bound in the active site. The more information available about ligands of the protein the better.
1. First, be able to define what exact role the target plays in the normal and/or diseased condition.
I'll give more checks later. Cheers.
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