It is necessary to develop efficient and scalable methods of concentration, refining, purification and separation of the bio-active molecules from microbe.
Small molecules have been playing an important role in drug discovery and development by providing both new chemotypes and new targets.
Small molecules have been playing an important role in drug discovery and development by providing both new chemotypes and new targets.
Recently, there has been a pool of information available regarding novel bioactive compounds. Bioactive compounds that have been isolated from marine microbes are gaining much importance relevant to secondary metabolites for drug discovery. The microorganisms are isolated and purified from the marine water bodies by both conventional and innovative isolation methods.Now to overcome the difficulties and limitations associated with the cultivation techniques, several DNA-based molecular methods have been developed to bypass the culture-dependent approach.
The study of small molecules should be undertaken not only with an intellectual view toward understanding the molecular intricacies of life in more detail, but also with a practical view of benefiting from what these molecules may have to offer.Small molecules—the bread and butter of pharmaceutical companies—are compounds of low molecular weight (under 3,000 daltons) and diverse chemical composition.
http://www.the-scientist.com/?articles.view/articleNo/30825/title/Mining-Bacterial-Small-Molecules/
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