Viscerotropic infection is a pathologies identified by Magill et al. 1993. This article is published by the New England Journal of Medicine.
Hello Abdallah,
The molecular mechanisms for viscerotropism and dermotropism in Leishmania are still in research and is an interesting matter. Here I paste an answer of a similar question from a researchgate user:
"Its hard to say, the different Leishmania species show different proteins profiles during the infection and dissemination stage, in addition to the wide genetic and inmunologic background of the infected people. There are some evidence about it, the pacient inmunologic status its important to determine the tissular tropism of Leishmania or severity of the infection. In inmunocompromised pacients even a non-pathogenic trypanosomatid parasite can generate a disease http://www.who.int/leishmaniasis/burden/hiv_coinfection/en/ATMP7.pdf. The antigenic and pathogenic determinants are not fully known yet, please read this for an approximation http://www.kinetoplastids.com/content/1/1/1. Because the distribution of Leishmania is limited for the presence of competent vectors and how the geographic and ecological barriers affect them, also you have to consider the rol of the insect (saliva) as another important factor in how different species of Leishmania can have different levels of pathogenicity and tropism. This is a wide topic in research yet" https://www.researchgate.net/post/Why_do_different_species_of_leishmania_target_different_tissues_What_factors_dictate_the_tissue_specificity_of_the_infections2
There are many information about virulence factors and parasite-vector interactions that influence the transmission and clinical features of the resulting diseases. I hope this uncomplete answer can help a little bit.
Best regards,
Luís Enrique.
Thanks Luis. This is exactly the assumption that we did! i think for L. tropica. It may move through body fluid and attack spleen. Could you send me your email? i will be happy to keep in touch
Hello Abdallah,
I always thought about how different species of Leishmania can show dermotropic or viscerotropic behavior, is a very interesting subject for me ... I have always believed that the human factor is very important besides the role of vectors saliva. In my region (north of Colombia) Leishmania infantum commonly affects children causing visceral leishmaniasis and its vector is able to transmit at least 2 species of Leishmania (paper in process of publication yet), for a while we are vigilant about the possibility of cutaneous leishmaniasis cases in adults caused by L. infantum.
Im sending you my e-mail adress: [email protected], I´m glad to know that someone is so interested in this topic as I am. In this moment I´m working with ticks and tick-borne diseases, that two areas (ecology of leishmaniasis and rickettsioses) are my main interests of research. Thanks for write me, I will be in touch, if I can help you in some way please let me know.
Best regards from Colombia, Luís Enrique.
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