There is a lot of research showing that CFD is beneficial to diagnose cardiovascular diseases. For example low wall shear stress in human aorta indicate the potential risk of aneurysms or rupture. What I am missing is a hemodynamical parameter that a physician understands, e.g. a parameter such as fractional flow reserve that has been known to estimate the effects of a narrowed vessel and was used to determine the need for stenting (see FAME and DEFEL studies). Are you aware of similar parameters that can be calculated from flow simulation and directly used in diagnosis ?
GON parameter proposed by Shimogonya et al is one of the parameters indicating variation of wall shear stress in oscillatory flow as shown in this journal .
http://www.ajnr.org/content/32/3/587.full.pdf
Thank you for the suggestion. In the review http://onlinelibrary.wiley.com/doi/10.1002/cnm.1481/full
two large studies have been analysed. The authors conclude "(...) Cebral et al. work (2011, 210 incraniacal aneurysms) is in agreement with Xiang et al. (2011, 119 intracranial aneurysms) on complex flows being associated with rupture but disagrees on its relation to WSS". Since GON models fluctuations of WSS, perhaps this is the promising paramter. IMHO, more studies are needed to confirm this hipothesis. The publication by Shimogonya et al. studies only a few patients. Are you aware of more studies?
Thank you for your interest in my hemodynamic parameter, GON. I thought these might be useful to you. The former includes GON results from more cases:
http://www.ncbi.nlm.nih.gov/pubmed/23553330
http://www.ncbi.nlm.nih.gov/pubmed/22363053
Dr. Takahashi, thank you for your referral.
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