I'm trying to justify the reason for putting a drug in a nanoparticle as opposed to creating an antibody drug conjugate. Some disadvantages that ADCs have I believe are:

1. Off- target toxicity- if the linker is unstable, it would release the drug in the bloodstream which would allow drug to go to normal tissue. (One can argue that the linker between nanoparticle and antibody is also an issue, but perhaps because there are multiple antibodies per nanoparticle you still have the ability to bring the drug to the target without releasing it into the bloodstream).

2. Amount of drug in nanoparticles is greater than each antibody can carry - so greater efficacy

3. Not sure about this one - but due to smaller size of ADC, perhaps more of it gets nonspecifically taken by via pianocytosis by macrophages in the RES and more of it gets metabolized though I dont have evidence for this (anyone can verify this?) -where the Fc portion gets bound leading to degradation of antibody in the lysosome, and further release of drug into the system.

Can anyone verify the above and provide more advantages if any, thank you!