There are various Saccharomyces strains, which have the capacity to synthesize higher amounts of the bioactive compound melatonin during its growth and alcoholic fermentation (e.g., wine making process or in different growth media).

I would like to see a citation taking me to a paper that shows any fungus makes melatonin, can the two folks who replied send citations?

Dear Nancy,

One paper which may be of your interest could be the following one by Rodriguez-Naranjo et al. (see citation below)

J. Pineal Res. 2012; 53:219–224

https://doi.org/10.1111/j.1600-079X.2012.00990.x

and perhaps this one: https://doi.org/10.1111/jpi.12005

It would be of great interest to investigate and unravel gene cluster(s) behind such production.

Many species produces melatonin and other indole-derivative compounds, i.e. Chaga (Inonotus obliquus) and many polypore species from family Hymenochaetaceae, like willow bracket (Phellinus igniarius), Tropicoporus (Phellinus) linteus, Sanghuangporus sanghuang, S. baumii, S. vaninii etc.