Score 1 bioactives are compounds that have been experimentally confirmed to have a biological activity or pharmacological effect on a specific target. In network pharmacology studies, score 1 bioactives are used as starting points for network-based drug discovery and drug repositioning.

Score 1 bioactives are typically identified through high-throughput screening assays, such as biochemical or cell-based assays, or through literature mining of experimental studies. Once a score 1 bioactive has been identified, its interactions with other molecules, such as other targets, pathways, or diseases, can be predicted using network analysis methods.

Network pharmacology studies aim to identify new uses for existing drugs or discover new drugs by leveraging the relationships between molecules in biological networks. By integrating experimental and computational approaches, network pharmacology can identify novel drug targets, repurpose existing drugs, and optimize drug combinations.

In summary, score 1 bioactives are important starting points for network pharmacology studies as they provide experimental evidence for the biological activity of a compound and can be used to build and analyze biological networks to identify new drug targets and drug candidates.