Data required would include: Depths of aquifer(s), Recharge mechanism, Aquifer media, effects of vadose zone, Hydraulic conductivity of aquifer, land use, Anthropogenic factors, Physico-Chemical & bacteriological characteristics of the water.
You may wish to appy the "DRASTIC" and "GOD" methods of aquifer vulnerability to make your assessment. "Google" these methods for details.
All factors that make the resource vulnerable should be considered, whether surface water or groundwater. Use/consumption pattern and climate change are also significant contributors in assessing water vulnerability.