I am planning to do research on mechanism of antigen sifting and drifting of Rotavirus. I coudnt able to find the right papers. can anyone suggest me any methods or concept for studying this topic.
Here is a review that should get you started. In general you will need a way to measure each of the RNA segments in the virus. Probably RT-PCR coupled to cDNA sequencing would be the way to go.
As mentioned above by James RT-PCR with sequencing techniques enables exploration of viral evolution. You can go through the paper to get some idea. Here is the link to access the paper.