Hi Dear colleagues, We want to know which herbal extract may have efficient effect to increase antibody production and immune response in fish were experimentaly i.p. injected with a vaccine containing bacterial lysate plus herbal extract
Saponins are a natural adjuvant extracted from various plants and have been used as adjuvants in veterinary vaccines for a while
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1810383/
however, they haven't been widely studied in animals other than mammals
I agree with Dr. Brent's answer that within the herbal extract there are too many components that may not necessarily have an adjuvant effect on vaccines and many other components depending on their concentration could become toxic, others may even be immunogenic by themselves And that is not the effect you are looking for. The suggestion of the saponins seems excellent alternative.
Successes in your experiments.
I would consider adding melatonin to the bacterial lysate. If you do a rapid search in PubMed you'll find many reports conferming that melatonin may have an immunoemnhancing effect even in fishes. On the other hand, melatonin is also contained in plants.
Effects of melatonin on oxidative stress, and resistance to bacterial, parasitic, and viral infections: A review
Thanks Dr. Brent, I read this article Saponin is a good Idea but predominantly oral-administered in this studies
Dear, Indian herbal and as well as Chinese herbal extract enhance the both immune response in fish.
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