We are finalizing the manuscript where 50 ns MD simulations are presented on general anesthetic propofol bound to human serum albumin due to the drug pharmacokinetics and pharmacodynamics in the circulatory system. We devised and implemented the LIE, MM-PBSA, and MM-GBSA techniques to compare the predicted constants (Kdpred) of propofol at the PR1 and PR2 binding sites in the HSA protein.