The PRODRG software is a good starting point for getting topologies for molecular dynamics simulations. However, there are major and minor issues with force-field compatibilities, besides the fact that most of the time these topologies require extra parameterization. A trustable model demands the topology that can reproduce some experimental data, or the topology, which was previously published. A good start, for instance, is to calculate the heat of vaporization or solvation-free energy for a simulated molecule.