An observational study from the Nurses Health Study51 that included 83,779 women > 20 years of age found an increased risk of type 2 diabetes in those with low vitamin D status. A combined daily intake of > 800 IU of vitamin D and 1,000 mg of calcium reduced the risk of type 2 diabetes by 33%

https://spectrum.diabetesjournals.org/content/24/2/113

yes, vitamin D supplementation in deficient patients would prevent the development.of diabetes. The recommended dose would be 500 mg Vitamin D-3 every day for 3-4 months.

I don't think so although statistically many T2 diabetics may have low serum Vit D which is believed to be secondary to a low well-known cornerstone capture of insulin inside the beta-cells (the calcium). whenever low Ca , the produced insulin has no ability to be stored so as to be used when the cell is activated. you know each molecule of Ca can hold 6 molecules of insulin. Now I and my colleagues are working on that and when we get positive results , we will publish that. By the way, Vit D has toxicity when the dose exceeds 100,000 IU/week therefore in my clinic the T2 diabetics who need Vit D3 are given dose either as 5000 IU twice daily or 10000 IU once daily till biochemical exame of Vit D determined normal levels so no limited time for use. Mr. Paul if you are working on relationship of VitD3 with Diabetes, it is better to read more on methodology before starting that research so as to have a high scientific article

This is dependen of the osteoporosis situation of the patient

I do agree that monitoring of vitamin D levels be regularly done in diabetic patients and its supplementation be regulated based on these values.

Serum vitamin D levels are significantly reduced in patients with poorly controlled type 2 diabetes mellitus compared to those in subjects with well controlled type 2 diabetes mellitus. Please refer to: REV ASSOC MED BRAS 2019; 65(1):51-55

I fully agree with the expert opinión of Dr. Srivastava

Thanks Lalit Mohan Srivastava, Rafi-ul Razzuqi, Luis Rodrigo, Gulali Aktas for your comments and discussions.

Scientists have estimated the close relationship between vitamin D and diabetes. It regulates the level of sugar in the blood, as it enters the formation of beta cells, which in turn works to produce insulin. Therefore, a lack of vitamin D leads to reduced insulin secretion, and adjusting the levels of vitamin D regulates Insulin secretion from beta cells, as it activates insulin receptors. Therefore, taking vitamin D is a preventive factor for diabetes, as it reduces the risk of developing type 1 diabetes by 80%, and reduces the incidence of type 2 diabetes by up to 33%, but these rates have not been definitively proven. Many studies confirmed that diabetics who face a deficiency in vitamin D have an increased chance of accumulating cholesterol in the arteries, so the chance of developing heart disease and stroke is very likely, in addition to the occurrence of atherosclerosis.

I agree with the views and the scientific observations provided by Dr. Maged Gumaan Bin-Saad vis-a-vis correlation between Vitamin D , Diabetes and Atherosclerosis.

Thank you Professor Maged Gumaan Bin-Saad. My research has similar results of your studies.

Thanks to Maged Gumaan Bin -Saad for your valuable additions to the discussion.

Some experts recommend increased supplementation of vitamin D, while still staying well below the tolerable upper intake level (UL) of 2000 IU per day. These experts recommend an additional 200 IU on top of the AI, either from fortified foods, or from supplements. These higher levels may help to reduce the risk of osteoporosis and cancer.

It is important to note that vitamin D created from sunlight on skin is not known to result in toxic levels. Levels of vitamin D produced from sunlight are self-adjusting. Vitamin D toxicity is known as hypervitaminosis D. Toxic levels of vitamin D can cause abnormally high blood calcium levels. This can result in bone loss and kidney stones. Long-term overconsumption of vitamin D can cause calcification of organs such as the heart, blood vessels, and the kidneys. Vitamin D may play an anti-cancer role by slowing cell division. Sunshine is the natural source of vitamin D.

Thanks Murwan khalid Sabahelkhier for your valued contribution and your effort to make the discussion lively.

I agree with Murwan khalid Sabahelkhier sir.

Dear Sujan Mahapatra thanks for your response.

An observational study from the Nurses Health Study51 that included 83,779 women > 20 years of age found an increased risk of type 2 diabetes in those with low vitamin D status. A combined daily intake of > 800 IU of vitamin D and 1,000 mg of calcium reduced the risk of type 2 diabetes by 33%

https://spectrum.diabetesjournals.org/content/24/2/113

Dear Anmar Aldewachi you shared a piece of very important information that a daily intake of > 800 IU of vitamin D and 1,000 mg of calcium reduced the risk of type 2 diabetes by 33%.Thanks for this valued contribution.

Dr. Harasit Kumar Paul's comments are very much.pertinet and we have also found similar observation vis a vis relationship of Vitamin D type 2 diabetes alongwith ultimate cause of atherosclerosis.

Thanks Lalit Mohan Srivastava for sharing your observation. Thanks for your effort to make the discussion lively.

i think Dr Murwan khalid Sabahelkhier has enlightened us with a good answer

Thanks, Raya Al-Naimi for your interest in the topic and your accordance in opinion with one of the discussants.

yes Sujan Mahapatra

Vitamin-D is believed to help improve the body’s sensitivity to insulin- the hormone responsible for regulating blood sugar levels and thus reduce the risk of insuline resistace, which often a precursor to type 2 dibetes.

Thanks Palem Harinath , Abdulridha Taha Sarhan , Mahmoud Elkazzaz

Mahmoud Elkazzaz

Thanks, Mahmoud Elkazzaz

An observational study from the Nurses Health Study that included 83,779 women > 20 years of age found an increased risk of type 2 diabetes in those with low vitamin D status. A combined daily intake of > 800 IU of vitamin D and 1,000 mg of calcium reduced the risk of type 2 diabetes by 33%.

https://spectrum.diabetesjournals.org/content/24/2/113

Vitamin D is believed to help improve the body's sensitivity to insulin – the hormone responsible for regulating blood sugar levels – and thus reduce the risk of insulin resistance, which is often a precursor to type 2 diabetes. ... Ideally your blood level of 25 OH D should be 60ng/ml.

https://www.diabetes.co.uk/food/vitamin-d.html

Your multivitamin supplement can provide nutrients that your body needs for regular function and that are essential for blood sugar control and insulin sensitivity. The best multivitamins for diabetes have the nutrients you need and are safe and easy to take.

https://www.lark.com/blog/best-multivitamins-for-diabetes/

Thanks Chinaza Godswill Awuchi for your appreciable contribution.

I fully.support the observations pertaining to the positive role of Vitamin D in the prevention and management of type 2 diabetes mellitus.

Thanks Lalit Mohan Srivastava for your valued response. Though Vitamin-D has a positive role in the prevention of type 2 diabetes, vitamin-D deficiency is very common in a country like Bangladesh where there is ample opportunity for sun exposure.

Thank you dear for your recommendation

Vitamin D Deficiency and Diabetes Mellitus | IntechOpen

Recent epidemiological studies have indicated the association between VD deficiency and both type 1 (T1D) and type 2 ( T2D) diabetes ...

https://www.intechopen.com/books/vitamin-d-deficiency/vitamin-d-deficiency-and-diabetes-mellitus

Low levels of vitamin D is a prevalent issue in people with and without diabetes across the globe. Research has repeatedly found a clear association between low vitamin D levels in patients with insulin resistance and a high risk of developing type 2 diabetes, as shown in this 2011 study from Canada.

https://www.healthline.com/health-news/vitamin-d-may-diminish-risk-of-t2d#Vitamin-D-and-Diabetes:-Whats-the-link?

there is a relationship between bot specially in older population

Interesting question. Follow.

Thanks Chinaza Godswill Awuchi for your appreciable contribution. Many many thanks for the valued links you shared.

Tahnks Luis Rodrigo and Sotiris Folinas for your interest in the topic. I appreciate your response.

Vitamin D treatment has also been shown to improve glycemic control and insulin sensitivity in people with type 1 and type 2 diabetes and ...

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2994161/

Efficacy of vitamin D supplementation on glycemic control in... : Medicine

Conflicting evidence exists on the effect of vitamin D supplementation on glucose metabolism in subjects with type 2 diabetes ( T2D)...

https://journals.lww.com/md-journal/FullText/2019/04050/Efficacy_of_vitamin_D_supplementation_on_glycemic.14.aspx

In patients with prediabetes, vitamin D supplementation at moderate to high doses (≥1000 IU/day), significantly ...

https://academic.oup.com/jcem/article/105/8/dgaa335/5850844

Especially in the older population, there is a correlation on between.

Thanks Chinaza Godswill Awuchi for your valued response and the links you shared.

Dear Abrar Hossain Tasin thanks for the response.

Vitamin D deficiency was very common in our study population. In Vitamin D deficient patients, supplementation treatment improved insulin resistance and glycemic parameters. Vitamin D replacement may be a promising intervention for the primary prevention of insulin resistance syndromes

Thanks Murwan khalid Sabahelkhier for a very good piece of information. It is surprising that in a country like Bangladesh where sun avoidance is very very difficult, Vit-D deficiency is not uncommon especially in the urban population.

Very good discussion.

Dear Sujan Mahapatra thanks for your response.

It is convenient to do specially in children and old people

Thanks Luis Rodrigo for your response and your interest in the topic.

https://www.hindawi.com/journals/ije/2018/7908764/

Dear Suhad Mohammed thanks for the important link you shared. I appreciate your effort.

Article Vitamin D Supplementation and Prevention of Type 2 Diabetes

Article Glycemic changes after vitamin D supplementation in patients...

Article Vitamin D in health and disease: A literature review

Article The Effect of Vitamin D Supplementation on Glucose Metabolis...

Dear Dhifaf Zeki thanks for your contribution. I highly appreciate the valued links you shared. These are really helpful.

It may be an useful tool in debilitated patients especially if they have low levels of this vitamin in serum

Harasit Kumar Paul

Article Role of Vitamin D in diabetes mellitus and chronic kidney disease

Article Glycemic changes after vitamin D supplementation in patients...

A recent Canadian study showed that taking high doses of vitamin D supplements slows the progression of type 2 diabetes in people who have been newly diagnosed with it.

The study was conducted by researchers at the Canadian University of Laval, and they published its results in the latest issue of the European Journal of Endocrinology.

The team conducted a study to discover the effect of vitamin D supplementation on newly diagnosed patients with diabetes, especially those with low levels of this vitamin.

The researchers discovered that taking a high dose of vitamin "D" could improve glucose metabolism, in order to help prevent the development of diabetes and slow its progression.

The study indicated that vitamin D supplementation significantly improved the action of insulin in the participants' muscle tissue, after 6 months of taking large doses of it.

Dear Luis Rodrigo thanks for your response. Thanks for your interest in the topic.

Dear Nirmala S.V.S.G thanks for sharing the important links. These might help in better understanding of the topic. I appreciate your efforts.

Dear Maged Gumaan Bin-Saad thanks for your valued contribution. You have shared a good piece of information that a high dose of vitamin "D" could improve glucose metabolism, help prevent the development of diabetes, and slow its progression.

It is highly recommended especially in post-menopausal women and also in male older people