There are many variants of diabetes, some with reasonably well defined pathophysiology and others with many missing details. Latent autoimmune diabetes of adults has been recognized for decades but many details remain unclear, thanks to the magic of immune system.  I am curious about the implication of title of your project: "Automatic blood glucose Insulin regulation."  Do you have a working hypothesis as to how you intend to achieve this goal?

Thank you professor, I am interested about the this topic because,Type-1 diabetic patients (daily) they have to take insulin externally .In India ,most of the diabetes patient taking constant level of  insulin (even though they are taking very low or high food).Hence i tried this title ,based on the level of glucose why not automatically we have to inject the insulin to the human body ?so, i have completed all the related simulation works ,hope it shown good result ,can you suggest me what are the complexity ? can i continue? or if there is any alter methods to solve this problem ? also i am in need of your mail Id to share many thing related to this work.

Thank you professor.

This is a great topic. We know that diabetes is a collection of diseases and they all have very different pathophysiologies--what ties them together is eventually they end up with hyperglycemia. 

We know that there is about 5%-10% of people who have type 1 diabetes and this is autoimmune. They typically present with polyuria and polydypsia and weight loss and if they wait long enough they will be in diabetic ketoacidosis. While the majority of people with this will be diagnosed as a child or young adult there is a second peak later in life (50s). 

There is also a group of people (between the age of 35-50 in the US) Who present with atypical diabetes-- they are thinner, they do not have a family history of diabetes, they have normal lipids and they may have a personal or family history of autoimmune disease. If you ask your history carefully they will have had some periods of the "ploys" and weight loss but it stopped on its own.. They will usually present clinically with mild hyperglycemia and we think they have type 2. However, it is more likely  that they have LADA-latent autoimmune diabetes of the adult --or "slowly progressive" type 1 diabetes. They indeed have an autoimmune problem. If you test for c-ppetide and antibodies they look more like type 1 than type 2. They has been called "type 1.5" but the term LADA replaced it because other conditions such as MODY (monogenic diabetes of youth) and "double diabetes" have also been called type 1.5. 

If you are interested I gave a lecture at the American Diabetes Association Diabetes is Primary --called Atypical Diabetes. IT was been webcasted and you can find it on the ADA website. Good luck with your research.

Article Latent Autoimmune Diabetes of the Adult (LADA): a case repor...

Arangaswamy,

i will suggest a thourough literature survey, which I hope you have either done or are in the process of doing. There is no need to reinvent a wheel. As I alluded earlier, diabetes is a syndrome caused by a variety of single or combination of reasons. Not every aspect is fully understood. LADA is an interesting variant and will make for good project.

i am not certain about the segment of diabetics that may actually have LADA and misdiagnosed as T2D patients; quite a few non-obese adults have late onset of diabetes.

Best,

Thank you Prof.Jayshubrook, surely i will get touch with you