I'm trying to synthesize malonyl dichloride from malonic acid using POCl3 as the chlorinating agent. I'm adding dropwise the POCl3 at 0 Celsius degrees to the solid malonic acid and stirring the mixture for 30 minutes according to an article I read recently, but no reaction seems to take place. I left it stirring overnight but the next day what I saw was just the solid malonic acid stirring in the liquid POCl3. Any advice on how to help the reaction take place?
The reaction between malonic acid and phosphorus oxychloride (POCl3) to form malonyl dichloride can be a slow process. To help the reaction take place, you can try the following steps:
If the above steps still do not lead to the formation of malonyl dichloride, it may be necessary to try alternative reaction conditions or to consider using a different reagent for the reaction.
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