I definitely agree with Greg Petruncio! This could be done by putting a UV or RI detector at the end of the column, it will avoid TLC at all, and will give a chromatogram.
We use scale and paper cutter to cut TLC Plates . Many people cut their hands while doing it, moreover TLCs are not smooth and it is a time talking process (marking, tracing and cutting etc).
To overcome these problems, I invented a TLC cutting device which has following features...
1. It is very easy to use and almost safe to use.
2. It is very cheap.
3. It can be used by any person without any training. Very user friendly.
4. One can cut various sizes of TLC plates according to the needs.
5. Ideal for normal chemistry reaction monitoring but can also be used for cutting HPTLC plates.
6. Can be used for cutting glass TLC plates with suitable glass cutter.
7. No marking is needed to cut the TLC plates as it is pre-calibrated.
8. Occupy same space as that of TLC Plate.
9. One can see the TLC plate while cutting with transparent version.
10. Made up of hard and transparent sturdy material so ling lasting .
11. Comes with variety of materials and can be drafted according to the needs of clients. Some of the versions can be. colour printed.
12. Already tested with my colleagues and it is working fine.
Hope you find it interesting, please let me know if you are interested.
This should be a popular tool in any lab that wants to save money. It can be marketed on the internet with little difficulty; the hard part will be making it known to chemists who might buy it.
A rotary paper trimmer is another inexpensive tool for the job.
I would have made it an instrument but I wanted to make it very simple, it should be very simple and handy for chemists. For chemists who do daily chemistry, need a lot of small size TLC plates may be with different size. The beauty of this frame is that we can cut different size based on individual needs (for column or reaction monitoring and small prep TLC).