12 Questions 32 Answers 0 Followers
Questions related from Omprakash Tanwar
Dear all I am trying to dock some database structures for docking using GOLD software. When I used it in SDF file GOLD couldn't treat as the ideal structure (bond lengths are small when...
09 June 2020 5,219 1 View
I developed a device for cutting the TLC plates. This is my new invention and this design is registered. I wish to commercialize this product. Please let me know if it is useful for daily...
13 March 2018 4,769 14 View
Rf values (TLC and HPLC) are used to identify the drug molecules. However this information can be of great value in medicinal chemistry and drug discovery. I think there's a great correction...
31 December 2017 9,117 11 View
There are many organic compounds which cannot be easily purified by normal silica column chromatography. These compounds need to be purified by reverse phase column chromatography however...
13 March 2017 437 12 View
Dear all, I want to convert an ester to nitrile in one step. My structure contains base labile groups so I cannot use ester amine procedures. Is there any method through which I can easily convert...
10 January 2016 2,772 19 View
Dear all, The field of CADD has become young. Now it is required that there should be an open source CADD platform. This platform should contain the prepared protein for drug targets and proteins...
02 August 2014 6,273 6 View
We have isolated β -Glucuronidase (cleaves β-glycosidic bond) enzyme from E. coli and two other species. These enzymes were then tested for their glucuronidase activity on Glycyrrhizin (structure...
05 October 2013 6,209 8 View
I am doing the enzyme assay of my compounds for DPP-IV inhibition. My compounds are soluble in DMSO but not in tris buffer pH 7.5. When I make a stock solution (1mg/ml) in DMSO it is soluble but...
05 October 2013 6,265 4 View
I purchased a DPP-IV kit from CuaBio. Actually, I wanted to screen my synthetic compounds against DPP-IV enzyme but unfortunately I have purchased a kit with human DPP-IV antibody coated Elisa...
18 July 2013 8,378 2 View
Covalent docking
27 September 2012 1,900 9 View
I am performing a reaction in which I am adding ammonia in a solution containing acetyl chloride and my starting material. I get my final product with ammonium chloride. The final product is...
28 July 2012 4,596 16 View
I have synthesized some novel compounds for inhibition of DPP-IV enzyme, a hot target for anti-diabetic therapy. Can anyone help me in screening my compounds against DPP-IV enzyme? Thanks
24 May 2012 5,754 4 View
