Exercise and time to fatigue are very different in young and old mice. The research we perform tries to apply this to aging humans (obviously very different from mice). So I was wondering if this phenomenon continued in older (>1 year old) mice? The running wheel may reflect a situation "like" the 6-minute walk, but in this study there really was no difference in run time or distance. The treadmill test might have been more indicative, but at a 0-degree incline, work cannot be calculated. Have you continued this work?
Wallace Harrington
Thank you for your question Wallace. Unfortunately we did not perform similar experiments in older mice, and I have not continued this work. I was involved in this project as part of a mouse phenotyping core at a private research institution that no longer exists.
Thanks, Julio. My group had been studying diseases in aging and had investigated the NAD salvage pathway as a possible therapeutic which is why I asked the question. We were always careful to use aged mice as young animals (and these were quite young) perform very differently to aged mice. I will say that our interventions did not offer many benefits.
It's recommended to see this links
https://books.google.iq/books?id=h53jlOhFG60C&pg=PA21&lpg=PA21&dq=This+study+was+done+in+young+mice;+does+this+also+apply+to+older+animals?&source=bl&ots=Ooub-6OMwq&sig=ACfU3U11x2WbUY9Mg32SM1qyLwMHKNj_gg&hl=ar&sa=X&ved=2ahUKEwjUwum4oaLqAhWq8qYKHR2EB-gQ6AEwAnoECAQQAQ#v=onepage&q=This%20study%20was%20done%20in%20young%20mice%3B%20does%20this%20also%20apply%20to%20older%20animals%3F&f=false
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