I proposed in March 2020, in my article ˝Immune system and COVID 19˝ (DOI: 10.13140/RG.2.2.21811.99366) ˝factors that can contribute to the better immune system functionality are healthy balanced diet (with addition of vitamins and trace elements if necessary), moderate physical exercise, ingestion of polyphenols and natural antivirals, protection of nasal and oropharyngeal mucosa with mucosal care and protection products, and smoking cessation.˝
Well, today, some colleagues agree that protection of nasal mucosa can help in prevention and treatment of COVID-19 disease. I am glad to help!
Example:
https://www.total-croatia-news.com/lifestyle/46762-dr-alemka-markotic
Do you have any similar data or experience to share?
Thank you!
I think it makes sense to protect nasal and oropharyngeal mucosa as they are the first sites of SARS-COV-2 entry.
Dear Domina Petric
Protection of nasal and oropharyngeal mucosa with mucosal by smoking cessation is quite understandable but how products of protection works? what are they ? Please put some light on that topic.
Regards
Md. Israt Hasan
Preparations that contain saline marine water or hyaluronic acid or for example, EPID naso spray medical (has a lot of compounds including saline water and propolis) are examples of mucosal protective agents that can be used.
There have been patients reported by prof. Markotic (Croatia) that had no systemic infection (no viremia, no symptoms), but they were constantly positive on SARS-CoV-2 for weeks because the virus remained tightly bound onto their respiratory epithelial cells, and when they washed regularly nasal mucosa with marine saline water (for example, Aquamaris naso and oropharyngeal sprays) their tests were finally negative.
One remote possibility is use of lectins for surface immunity response?
1) Hua, X., Vijay, R., Channappanavar, R., Athmer, J., Meyerholz, D. K., Pagedar, N., Tilley, S., & Perlman, S. (2018). Nasal priming by a murine coronavirus provides protective immunity against lethal heterologous virus pneumonia. JCI insight, 3(11), e99025. https://doi.org/10.1172/jci.insight.99025
2) Impact of Nasal Saline Irrigations on Viral Load in Patients With COVID-19: ongoing clinical trial, awaiting results
some useful links!
There are some hints for existing IgA antibodies (cross reactive from former coroan infektions) against SarsCov 2 . From natural medicine we know that cystus pandalis (R) has antiviral effects, also known for anti influenza effects. H2O2 solutions will probably harm the mucosal microbiom ,so natural solutions together with vitamin D and zinc can help against SarsCov2 infections.
Have a look at these useful RG links.
Article Nasopharyngeal wash in preventing and treating upper respira...
Article Nasal Disinfection for the Prevention and Control of COVID-1...