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In recent years, the wide availability of complete genome sequences has changed the way we think about vaccine targets. From a few dozen potential targets we can now count on hundreds of targets per organism. This candidate vaccine is an extensively scrutinized plethora based on the concept of reverse vaccinology (RV) with special attention reserved for exported targets, generating promising results for various organisms. However, it should be borne in mind that we still lack effective vaccines for organisms sequenced within a decade, a period much longer than expected for producing an effective vaccine by RV. This consideration leads to the reflection that, in the research on a vaccine, other variables may be as important as choosing a target exported. Attention is paid to the fact that the universe of possibilities for an effective vaccine can be exponential in order of 2^n where n is the number of variables. This review compiles results of some key research using the concept of RV and raises some potential issues that may be hindering the efficient use of this technique to attain attractive and promising targets for vaccine research.
Article The reverse vaccinology – A contextual overview
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