Synthesis: Who knows the method for synthesis of Z-His-Trp-OH?

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How can I identify the structure of Fmoc-Tyr(trt)-OH and remove the Trt group from carboxyl?

I tried to synthesize Fmoc-Tyr(trt)-OH and got a solid that was not dissolved in any solvent, even in a different pH (acid or base). I now doubt that it was Fmoc-Tyr(trt)-OTrt and would like to...

01 February 2014 9,805 5 View

What is the best way to product fmoc-Ser(trt)-OH?

I want to make Fmoc-Ser(trt)-OH, do you know any suitable methods with high yield? I have a problem especially in H-Ser(trt)-OH synthesis, that the alcohol side chain is protected by Trt.

07 August 2013 7,828 5 View

Rink amide resin?

I am using rink amide to synthesis a peptide with c-terminal as CONHCH2CH3. After cleavage the peptide from resin I will have CONH2. How can I change it to CONHEt with the regards that I have...

07 August 2013 7,407 3 View

How should I react rink amide resin?

I am using rink amide to synthesis a peptide with c-terminal as CONHCH2CH3. After cleavage the peptide from resin I will have CONH2. How can I change it to CONHEt with this regards that I have...

07 August 2013 4,456 3 View

In solid phase synthesis, if I use HOBt in situ, does the excess of HOBt make any problems in coupling step?

07 August 2013 7,212 2 View

How to calculate CCS for Sodiated adduct ions and Multiply Charged Ions?

I'm currently working on calculating the collision cross section (CCS) for various ions, and I'm facing challenges when dealing with sodiated and multiply charged ions. Most of the resources I’ve...

08 August 2024 8,329 0 View

Inquiry on Maximum Nucleic Acid Volume for 2.5 mL Liposome Solution?

I am currently working on a project involving liposomes and need to determine the maximum volume of siRNA that can be added to a 2.5 mL liposome solution with a total lipid concentration of 10...

30 July 2024 6,420 1 View

How can I use DFT-D3 correction ( Siesta version 5.0.1)?

Dear Siesta Users, I installed Siesta 5.0.1 and I want to use Grimme's D3 correction. According to the 5.0.1 manual, I could use a few parameters to include the D3 correction in the...

27 July 2024 5,748 0 View

EDC carbodiimide and NHS easter 's half life among different pH?

It has been long known that EDC carbodiimide and NHS easter's half life agains hydrolysis are highly related to pH. However, very surprisingly, not yet found a paper giving a table/chart of their...

25 July 2024 8,738 0 View

Mechanochemistry: ball to powder mass or ball to powder volume?

I run mechanochemical reactions that involves the use of a large amount of catalyst (1:1 molar ratio to the reactant). When I try to understand the effect of amount of catalyst on the reaction, I...

23 July 2024 9,938 1 View

How to eliminate the carry-over effect in GC-MS/MS system?

Hi, I am a PhD student working at Jagiellonian University, Faculty of Chemistry. My work is related to the development of new analytical methods for the quantification of short-chain fatty acids...

22 July 2024 5,492 6 View

I want to buy Hydrothermal Synthesis Autoclave from any European company. Can anyone suggest any company inside Europe?

Thanks

22 July 2024 1,143 3 View

Hi dear researchers, do you suggest the best and shortest path for chemical synthesis and green synthesis of magnetite(Fe3O4)?

Suggest the best and shortest route for the chemical synthesis and and green synthesis of magnetite(Fe3O4) The chemical synthesis should contain the least dangerous chemicals along with full...

21 July 2024 2,476 2 View

MDCI module in Orca software?

Dear Researchers, My question is associated with the "MDCI" method in Orca. Please let me clarify my question using a simple example: Suppose we are going to perform CBS extrapolation using "!...

21 July 2024 1,632 0 View

Im trying iodination of an arene, but only getting black precipitates, is there anyone with iodination experience who can advise?

Organic Synthesis. My student has been trying iodination of arenes (our goal is to iodinate p-phenylenediamine) following these literature procedures: 1. Synthesis 2004, No. 11, 1869-1873 using...

16 July 2024 6,630 1 View