Luigi Grassi

7 Questions 49 Answers 0 Followers

Questions related from Luigi Grassi

pH depence of pyroglutamate formation from Gln different tahn from Glu?

The degradation pathways leading to Asn degradation are quite different from those of Asp (e.g. Asn is hydrolised at pH 1-4, is stable between pH 4-5 and undergoes general buffer catalised Asu...

11 November 2018 3,475 0 View

2,1,3-Benzoxadiazol-4-amine, 7-(4-morpholinyl)- 842964-18-5 reactivity with thiols?

Does anybody have any clue concernoing any possible reaction that the mentioned compound could give with thiols in water? thank you for your interest

07 July 2015 7,179 0 View

Can someone help me with diethylamine induced peptide degradation?

DEA treatment of an Fmoc protected peptide in solution caused degradation of the material as detected by analytical HPLC...has anybody any clue about what could be ever going on? Thank you for...

05 May 2015 764 3 View

Is my oxazolidine breaking in TLC giving the stating materials?

I am trying to synthesise an oxazolidine between OAc-Salicylaldehyde and diethanolamine.Following a procedure found in the literature, 1.1 eq of diethanolamine and the aldehyde, in presence of...

10 October 2014 5,283 8 View

Would a phenyl ester withstand repetitive FMOC removal cycles performed with DBU/HOBT 80mM/74mM?

Each cycle would be done with 2 treatments, 1 min each. Topic is phenyl esters hydrolysis.

07 July 2014 274 5 View

Can anyone help with resin hydrolysis of oxazolidine ring?

I got an amino acid salicyl aldehyde ester attached through N Boc protected oxazolidine ring, to a Ser derivatized resin and I want to cleave the oxazolidine keeping the ester linkage.Could anyone...

07 July 2014 8,260 9 View

Does anyone have tips for the synthesis of a peptide C terminal Salicyl aldehyde?

I tried to make the reaction with DCC DMAP or DCC/HOBT between a protected peptide with the protected Salicyl aldehyde (as dimethyl acetal). The first time it came more or less good, then when I...

05 May 2014 2,021 3 View