What is the best way to product fmoc-Ser(trt)-OH?

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Jingxian Yu

Could you please advise what starting material you are going to use? Otherwise, the answer can be very complicated.

Ondrej Zvarec

I'm assuming u want to protect H-Ser(trt)-OH with fmoc, if thats the case i would use fmoc-oSu+ mild base since trt is acid labile

Joseph J Barchi

Why not simply purchase it? Very common and cost only ~$15/gram USD

Maxim Antopolsky

Just do not start from unprotected Ser. Use commersially available Fmoc-Ser(tBu)-OH and then change side protection for Trt.

Raviraj A Kusanur

Fmoc-Osu inpersence of organic base.