Struggling to download Maestro by schodinger for small molecule drug discovery, does anyone has zip file?

More Pankaj Bhandari's questions See All

What are anisotropic electrical and optical properties of a semiconductor due to?

In some materials, properties such as band gap, thermal conductivity differ along different crystallographic axes. What are the basics?

01 March 2021 1,923 3 View

How to decrease the time for publication of paper in a journal ?

It takes a lot of time in publishing the paper in the journal, from few months to a year so how one can able to decrease the time for publication.

17 February 2021 2,997 14 View

What is your philosophy about life ?

how do you understand life as it is really big suspense, why we are here, our consciousness is big unconsciousness and our unconsciousness big consciousness.

25 December 2020 7,632 19 View

What is the essence of bio electricity inside us ,why it get resonate during meditation ?

Many time during meditation whole body feels the flow of electricity like the thing is it bio electricity or something else why this occurs but after that generally, I felt so miracle...

25 December 2020 3,754 3 View

What the essence of yoga and meditation ,how you take it as?

we all have our own thought and experience regarding yoga and meditation, we all know it's a miracle unexplainable to those who do he/she feel it.What's your view regarding it.

24 December 2020 3,615 10 View

How ash helps in controlling pest,disease control ,is it good to apply or not ?

we all know that it is our traditional practice which we are performing in any problem in our kitchen garden to farm level is it good to apply or not, how it is good or what are its effects.

24 December 2020 2,699 15 View

What is the role of fresh cow dung in sprouting in stem cutting propagation?

In my personal experience I have find the higher rate of sprouting when fresh cow dung is applied on the top side of cutting what might be its reason.

24 December 2020 4,068 6 View

Why the taste of foods(item) changes with the sources of fuel we used(bio fuel,wood,dried dung) reality or meth ?

As my experience and many consumer experience they feel the different taste of the same item served cooked in a different source, is it real or not, what is the reason behind this.

24 December 2020 6,476 3 View

Do you think knowledge should be in equal access to everyone ?

everyone knows the importance of knowledge but knowing this too why there is a restriction in getting access to it what is reason behind this.

23 December 2020 2,934 6 View

What are the challenges for organic farming and its commercialization ?

Knowing the overall hazardous effect of chemical farming too we are not getting away to organic farming, even on a small scale or on a large scale in too so what will be the challenge during the...

23 December 2020 2,274 24 View

I am interested in medicinal chemistry field, which books are highly recommended to learn from?

I am at the beginner level in drug design and drug discovery, and I am interested to learn more about this field. Which books are highly recommended to start from and gives me all essential...

02 March 2021 8,437 2 View

Problem with shRNA transfection. Why are only two plates getting contaminated instead of all?

I transfected my LNCaP-WT cells with 3 shRNA plus their NTC two weeks ago and split two puromycin selected cell plates on Friday last week(Feb 26). I checked for GFP in the cells, and they all...

28 February 2021 4,949 3 View

How to empty large intestine in mice ?

Hi all I am working on colon-targeted drug delivery for which I kept mice fasting for 6h using fasting grills during scotophase (dark period). I observed liquid fecal content in the cecum and...

23 February 2021 7,701 2 View

Can I use a protein-devoid condition as my negative control in ELISA?

Hello, I am running a sandwich-type ELISA where I am trying to inhibit a protein-protein interaction using small molecules. For each experiment, I determine my Z' (Z-prime) to determine the...

23 February 2021 7,429 1 View

How does the injection volume impact LLOQ and ULOQ in regression analysis (LC-MSMS)?

Hello, I have run into an issue that has sparkled a debate at work: is the LLOQ/ULOQ impacted by injection volume under the following circumstances: 1) Same dilution factor of all samples 2)...

23 February 2021 9,159 3 View

Can two EC50 values with different hill slopes be compared?

Hello, I fit a classical dose response curve Y=Bottom + (Top-Bottom)/(1+10^((LogEC-X)*HillSlope)) to my data (not related to inhibitors etc). The model I use is purely qualitative but it fits...

23 February 2021 8,155 5 View

Which alginate is best for making gel for wound dressing application?

We are looking into utilizing alginate as a gel coating on an HDPE substrate for drug delivery. I would like to ask the community about their experience with alginate and which commercial sources...

15 February 2021 4,319 4 View

Any natural extract (that is easily available) or any drug combination triple which i can use against gram negative?

I'm working on gram negative i want to use any natural extract (plant extract) or triple drug combination against its biofilm formation.

14 February 2021 1,403 3 View

Should the AUC in a concentration-time graph of a subcutaneous implant be roughly the same for poeple?

I have 2 concentration time curves of a subcut drug implant. the first group has a peak around the 50 day mark where as the second group does not. Both groups received the same implant by the same...

10 February 2021 2,305 3 View

XRPD Quantification - Building a calibration curve of drug excipient?

I am aiming to utilise XRPD to quantify a drug excipient within a drug product and have been having a little trouble building the calibration curve to allow for this quantification up until this...

10 February 2021 6,145 3 View

Jameel M. Abduljalil

Based on my experience with Maestro last year, the free-for-academic version is very limited and you will use it just for visualization purposes. License is too expensive and don't expect somebody to share it with you.

Better to switch to open-source software.

Pankaj Bhandari

Seems like the only option left, thank you for sharing your experience Jameel M. Abduljalil