Hi all, is it possible to do a meta-analysis of randomized controlled trials with factorial design? I would appreciate some guidance/referral to a statistical resource or guide on this. Many thanks.
Hi! I remember reading up on this in the Cochrane Handbook for Systematic Reviews of Interventions, and this section (and the entire Chapter where it belongs) might give you initial guidance: https://training.cochrane.org/handbook/current/chapter-23#section-23-3-6.
Yes, Aedrian Abrilla provided a great source to find the answer.
You may also refer to the underneath meta-analysis paper that included studies with factorial design:
Griffin SJ, Leaver JK, Irving GJ. Impact of metformin on cardiovascular disease: a meta-analysis of randomised trials among people with type 2 diabetes. Diabetologia. 2017 Sep;60(9):1620-1629. doi: 10.1007/s00125-017-4337-9. Epub 2017 Aug 2. PMID: 28770324; PMCID: PMC5552849.
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