Can anyone suggest the standard molecule for molecular docking and MD simulation for dual inhibition of EGFR & HER2?
There is no specific protein standard in molecular docking, you can look for it directly in the RCSB PDB data base, according to what you need for molecular docking.
What is the exact mechanism of synthetic agents showed the cell cycle arrest in G0/G1 and G2/M2 phase in flow cytometry analysis.
28 June 2024 5,950 2 View
Hey all what are the ways by which an encapsulated drug inside BSA may escape from its encapsulation. We had synthesised curcumin encapsulated BSA by desolvation method followed by centrifugation...
23 June 2024 8,785 5 View
Dear experts, I am new to molecular dynamics and can run simulations on small Liquid crystal systems using GAFF in GROMCS. I wanted to use the GAFF-LCFF forcefield (Optimization of the GAFF Force...
11 June 2024 4,547 2 View
Hey all I have tried synthesizing Albumin nanoparticles using desolvation technique using glutaraldehyde as a cross linker. After 24 hrs of stirring I could see that the protein has turned brown...
04 June 2024 1,501 0 View
Is Cell the unit of living organism / life? Absolutely incorrect. Explanation: From fossils cell we have estimated , before how many years it was there, e.g 40millions years etc.. Was that cell...
28 May 2024 5,931 1 View
Any latest method developed
24 May 2024 2,128 1 View
Can we restrict the vertical and horizontal displacement in two directions for the lower semicircular in bottom hole of CT specimen and apply incremental displacement in the upper semicircular in...
09 May 2024 5,273 4 View
Hey all I intend to isolate free circulating SiRNA in media using chloroform extraction. I have added chloroform to media containing SiRNA to get the phase separated. The Chloroform came in the...
17 April 2024 8,522 3 View
Hey all I wish to know the change in expression level of certain genes post treatment with drug. For this can I isolate RNA after 24hrs of treatment? Should I wait till 48 hours? Or should I...
06 April 2024 9,082 0 View
Since some gene prioritization tools were published in the last decade, there has been no new research in the area of gene prioritization or candidate gene discovery. Can somebody shed light on...
05 April 2024 4,625 1 View
Hi, I know that low molecular weight (MW) molecules generally tend to have higher mobility, while high molecular weight molecules tend to have lower mobility. However, in my experimental...
06 August 2024 1,495 2 View
kindly reply me. Thanking you in advance.
05 August 2024 7,727 4 View
Is it possible to conduct a molecular dynamics simulation to see the effects of a specific carbohydrate on the structure of lipids (e.g., micelle structure)? I am a beginner in this field and plan...
03 August 2024 3,371 3 View
I am using a windows system, what software I should use for hydration shell analysis with molecular dynamics?
02 August 2024 3,143 4 View
Molecular docking software/ websites?
02 August 2024 8,704 7 View
Can we patent a process flow diagram developed using a process simulator but no actual cases is carried out? For example consider a process for certain product manufacture where a new process flow...
31 July 2024 781 1 View
I am currently working on a project that involves extracting cell membranes, for which we disrupt the cells using sonication. During the initial extraction process, we add protease inhibitors to...
30 July 2024 7,077 1 View
Dear all, I am working on particle deposition in human's & rat's respiratory airways using CFD and I am looking for the 3D CAD file for my simulations (STEP or IGES format). If somone has such...
29 July 2024 1,092 2 View
Dear All Gromacs User I would like to restart MD without using checkpint .cpt files? I heard there is a way for acheiveing this. Any input and sugegstions are most welcome. Thanking You Budheswar
29 July 2024 3,084 8 View
Good day, I am a student trying to work on Autodock for a project regarding Ligand-DNA interaction so i am quite new to molecular docking. i have followed tutorials and did all the steps...
28 July 2024 2,136 4 View