Some maintain that an S clamp (G or C) makes for better priming, other say it makes it worse. What are your suggestion on this matter?

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Zinah Ghazi

The GC content (the number of G's and C's in the primer as a percentage of the total bases) of primer should be 40-60%

Because you know, there are 3 bonds between G and C

when there are only two bond between A and T so if the ratio was much it will affect the process of ligation and melting of the primer and will need high temperature may adversely affect the process of DNA replication.