Hello,
I have been trying to prepare solution of glucose, mannitol and aspartame each separately to find the drug impact of each of these solution over cells. Hence am looking for a solvent that is cell friendly. Can water be picked up as a choice of solvent
Dear Swarnapriya Kasi,
The following are the solubility of the three compounds:
Aspartame:
The solubility of aspartame in water is dependent on pH and temperature, the maximum solubility is reached at pH 2.2 (20 mg/mL at 25 °C) and the minimum solubility at pH 5.2 (pHi) is 13.5 mg/mL at 25 °C.
Soluble in DMSO, and methanol.
Mannitol:
Solubility in water 216 g/L
Glucose:
Solubility in water 909 g/1 L (25 °C (77 °F))
As you can see from the solubility values; mannitol and glucose are very soluble in water. The only problem is the low solubility of aspartame in water at pHs above 5.
It depends on how much aspartame you want to dissolve in water, if the quantity is small and falls within the solubility range, you can use water as a solvent. However, if the quantity to be used is high you should switch from pure water to mixture of DMSO/water.
Hoping this will be helpful,
Rafik
What is the suitable solvent to dissolve Aspatame . Please I need to feed it to rats and the solvent should be harmless since it's not dissolving in water
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