I am working on hydrophilic drug which is very prone to hydrolysis and thermal degradation. I need to make solution of this drug with extended stability for 9 months. Please share your views.
I think mesoporous silica particles having smart gate keepers can be the suitable carrier and safe cage-storage for your hydrophilic drug. In this case you have to choose suitable polymers and targeting ligands to reach the drug to the desired site. You can follow our recently published papers:
Mesoporous magnetic silica particles modified with stimuli-responsive P(NIPAM-DMA) valve for controlled loading and release of biologically active molecules. June 2018, Soft Matter 14(26):5469, DOI: 10.1039/C8SM00560E