Should I ignore an initial burst for drug release while examining the appropriate drug release model?

More Kevser Sevim's questions See All

I would like to quantitatively detect total bacteria in mice feces. How can I obtain a standard curve to reveal total bacteria quantitatively?

Basically, I would like to quantitatively detect total bacteria in mice feces. How can I obtain a standard curve to reveal total bacteria quantitatively? By the way, I have one bacterial species...

23 January 2024 9,254 2 View

Disulfide bond loss at high temperature in MD simulation?

In MD simulation, I see that the peptide loses its disulfide bond as a result of high temperature application. I can't see the disulfide link in PyMOL, but I can see a link with the SG code in the...

15 April 2023 3,604 1 View

How can I identify a bacterium?

Hello everyone, I have the complete genome sequence of a bacterium in an assembly form. How can I easily and practically determine which strain it is? Also, how can I find the 16S rRNA of this...

10 December 2022 6,965 3 View

How do I calculate the protein content from absorbance and standard curve and express as g/100g or percentage?

I did bradford assay and I want to calculate the amount of soluble protein in my glycoprotein sample. I prepared BSA stock of 1mg/ml and did a standard curve ranging from 0.01 to 0.16 mg/ml. I...

06 December 2022 604 0 View

What is the storage condition of freshly prepared OPA reagent?

How do you store OPA reagent made from scratch and how long can it be stored for use?

22 March 2022 1,655 2 View

How can I fix GROMACS genion error?

I follow the protein-ligand simulation tutorial protocol. For my own protein-ligand simulation, I give the following commands at the ion addition stage: gmx grompp -f ions.mdp -c solv.gro -p...

04 January 2022 9,353 1 View

Is there a method by which I can analyze the conformation of proteins at various temperatures in silico?

I want to analyze the responses and conformational states of proteins at various temperatures in silico. Can I do this with molecular dynamics simulation programs like gromacs? Is there a special...

10 December 2021 7,520 3 View

How can I remove PMMA solution from graphene surface without damage?

I am working on graphene growth on copper foil using CVD. I use PMMA solution to protect the graphene after the growing process. Before transferring the graphene onto SiO2/SiO, I use acetone to...

11 November 2021 681 22 View

How can I determine serum quality from an archived sample?

I have serum samples collected by someone else. I am not sure samples collected properly that's why I want to check their quality before doing an ELISA assay. Is there any validated...

06 May 2021 4,829 4 View

Do the attached photos show contamination in the cell culture study?

While our studies were going on, we noticed long thin formations around the cells as in the photo. While trying to understand what was happening, we saw that it was also in the newly opened...

03 January 2021 6,493 1 View

Could you recommend some articles on Urban Transportation System optimization and Innovation?

13 August 2024 2,595 3 View

For an in-vitro drug release study, what molecular weight cut-off (MWCO) dialysis bag is required for a 117 kDa protein?

kindly reply me. Thanking you in advance.

05 August 2024 7,727 4 View

A Question about Phd thesis?

Hello everyone What is your opinion about the introduction of an expert decision support system in which the rules are extracted from existing data without human intervention, instead of being...

31 July 2024 5,785 4 View

Inquiry on Maximum Nucleic Acid Volume for 2.5 mL Liposome Solution?

I am currently working on a project involving liposomes and need to determine the maximum volume of siRNA that can be added to a 2.5 mL liposome solution with a total lipid concentration of 10...

30 July 2024 6,420 1 View

After a lot of feature engineering for CTR modeling, it feels like it's basically the end of iteration? I mean, it's not cost-effective to keep doing?

After a lot of feature engineering for click-through rate modeling, it feels like it's basically the end of iteration? I mean, it's not cost-effective to keep doing it?

29 July 2024 4,955 0 View

How to use Desmond in HPC ?

Our department has recently acquired an HPC (High-Performance Computing) system, and I'm thrilled to take my molecular dynamics calculations to the next level using Desmond. I used to run my...

28 July 2024 6,553 1 View

Can we eliminate the stress singularity at the tip of the crack by manipulating the elastic constants?

The aim of the research here is to prevent the propagation of the crack in the fabricated elastic medium with useful applications.

25 July 2024 9,976 3 View

Look for qualified candidates of Visiting Scholars to Southwest Jiaotong University?

We invite qualified candidates of Visiting Scholars to engage in research collaboration or deliver lectures on their research, with travel expenses covered. The visiting period is flexible,...

20 July 2024 1,165 1 View

What is the suitable solvent of MIL-100 for chemotherapy?

I synthesised a nanocarrier by conjugation MOF (MIL-100) with folic acid for use in chemotherapy but the samples didn't dissolve completely in aqueous solution or DMSO. Instead, they only...

19 July 2024 8,522 0 View

How to extract binding energy from pv.maegz file without using Schrodinger?

I have conducted virtual screening using Schrödinger on a database of 17,000 molecules. Unfortunately, I cannot use the system with the Schrödinger license at the moment. I am trying to find a way...

18 July 2024 2,881 4 View

Khaled Al-Tahami

You should include the whole release profile in your modelling.. otherwise higuchi release could turn into zero order easily. burst release is is part of your whole picture and once you reduce it you could fit your data into a zero-order release.

Kevser Sevim

Thanks for both of the answers.

Jagadevappa S Patil

Dear Prabhanjan,

It depends on situation and your requirements. Some time initial burst release may be considered important.