Reports in literature suggest that Covid-19 patient are more likely to be at higher risk for VTE and other bleeding conditions. Should there be need to place positive patients on thromboprophylasis as a means of preventing bleeding challenges while patients is on treatment?
the decision should be based on the patient's general condition, symptoms and laboratory test results. Extreme caution should be used among middle-aged people
Thanks peter dirscherl
Thanks Łukasz Szarpak
But are there specific symptoms and signs that must be in place, or lab results patterns that should inform the decision of the care giver to administer thromboprophylasis to Covid-19 patients?
Well the release of Fe3+ ions from the decomposition of hemoglobin and lysis of RBCs can result in very hydrophobic fibrinogen-RBC matrix which can result in severe blood clot formation.
1. Wenzhong L, Hualan L. COVID-19: Attacks the 1-Beta Chain of Hemoglobin and Captures the Porphyrin to Inhibit Human Heme Metabolism. 2020 Apr 13 [cited 2020 Apr 24]; Available from: https://chemrxiv.org/articles/COVID-19_Disease_ORF8_and_Surface_Glycoprotein_Inhibit_Heme_Metabolism_by_Binding_to_Porphyrin/11938173
2. Pretorius E, Bester J, Vermeulen N, Lipinski B. Oxidation Inhibits Iron-Induced Blood Coagulation. Curr Drug Targets. 2013 Jan;14(1):13–9.
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