Dear Kinetic experts,
I need one kind suggestion from you. One X compound with molecular weight of 200.1, is highly water soluble with oral bio-availability of 65-75%. In that case I want to achieve 1 micro mole in plasma (irrespective to protein bound %) for that how much dose I should give by orally. Is that any standard formula is available for this calculation?
Please note that in my study design, if the compound reaches more than 1.5 micro mole it will become inactive. So specific concentration in plasma is really challenge. Please help with this
Thanks
Dear Murugesan,
Please look in to below calculation that might be useful.
Calculation:
200.1 g/mole
1 mole = 200.1 g
1 micro mole = 200.1 mcg
Oral BA is 65-75%, means average 70% (for calculation purpose only)
1 micro mole provide approx. 70% plasma BA i.e. (200.1 x 0.70 = 140.07 mcg)
70% BA achieved from 200.1 mcg (is equivalent to 140.07 mcg)
So, 100% BA achieved from 285.857 mcg (is equivalent to 200.1 mcg)
So considering above calculations proposed oral dose should be 286 mcg which provides 1 micro mole in plasma.
Regards
Hitesh Chavda
Thank you Hitesh Chavda . Please share any citation for this formula
Dear Murugesan Arumugam,
Pl refer link (page 22-23) for calculation of loading and maintenance dose based on PK parameters.
https://www.pharmpress.com/files/docs/clinical_pharmacokinetics_samplechapter.pdf
Regards
Hitesh Chavda
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