Also: regarding resveratrol(Red Wine), I submit the following: Resveratrol has been proven to have antiviral properties. It appears to be the 'drug of choice' to treat pseudorabies (a virus) in hogs. I propose we give research consideration to resveratrol as a prophylactic measure and maybe even as an adjunct treatment in the COVID-19 (SARS-CoV-2) Pandemic. July 07, 2020.
(Also note, that the pseudorabies virus has been considered as an attenuated carrier virus for SARS-CoV-2 fragments in the use of a new vaccine for the Novel Coronavirus. Thank you, stay safe while considering this information.)
Yes, this could be pragmatic strategy. Earlier, it has been demonstrated that RSV effectively inhibits MERS-CoV infection in vitro by down-regulation of nucleocapsid (N) protein. Kindly refer to the link provided below:
Article Effective inhibition of MERS-CoV infection by resveratrol
I assume that the treatment of hogs with pseudorabies, such as in Portugal, involves the feeding of the hogs the left over skins and seeds of the red grapes after pressing for the juice to make wine. These are the richest part of the grape in resveratrol. People drinking the final product, the red wine, may also be getting the prophylactic benefits of this same "medicine."
Article on inhibition of CoV by resveratrol:
Bioactive natural compounds against human coronaviruses: a review and perspective
- May 2020
- Acta Pharmaceutica Sinica B
- DOI:
- 10.1016/j.apsb.2020.06.002
- License
- CC BY-NC-ND 4.0
- 📷Yanfang Xian
- Juan Zhang
- 📷Zhao-Xiang B. and:
- Lin SC, Ho CT, Chuo WH, Li S, Wang TT, Lin CC. Effective inhibition of MERS-CoV infection by resveratrol. BMC Infect Dis 2017; 17: 144.
There are over 500 plant derived compounds that are being studied for antiviral properties, including against SARS-CoV-2. I t would take a book to described them all. I will only mention a few here. Many others can be searched on the web. First, natural quinine is plant derived, works very well as an antiparasitic, and is the drug of choice when hydroxychloroquine resistant malaria is present. But it is also antiviral, and eradicates the SARS-Cov-2 in vitro experiments. It has been used successfully anecdotally prophylactically, but there are no published double-blind placebo controlled clinical human experiments yet. Then there is resveratrol, again shown to kill SARS-Cov-2 and other coronaviruses in vitro, but not yet published in a well controlled double-blind placebo human clinical study. Nothing is accepted until this gold-standard is met. Coincidentally, resveratrol is used in its natural state (grape-crush) to treat another virus in hogs, "pseudorabies" as the usual "drug of choice." Pseudorabies virus is a candidate for the 'attenuated' carrier virus for a potential SARS-CoV-2 vaccine. The third I will mention, is the chemicals in "black tea." The extract has been shown to eradicate SARS-CoV-2 in vitro, probably due to n-methyl xanthines it contains. Again, no 'gold-standard' studies have been published on this yet. I will point out that currently these should not be considered as treatments or cures, with the information so far showing that they may have some prophylactic properties that may be found to be useful after further clinical study. This is suggested by some anecdotal information to date. There are no studies as to the dose required in the 'gold standard.' A similar statement could be made for hundreds of other plant derived antiviral chemicals. (An anecdote as to the dose question is this: 65% ethanol also kills the SARS-CoV-2; but the amount needed to kill it in a persons body would probably kill the person. So the dose is important in this discussion) July 30, 2020 Gary Ordog, MD