What is the state of the drug inside solid lipid nanoparticles (SLNs)?

I am a little confuse with the mechanism of solid lipid nanoparticles (SLNs). The main point of encapsulating drugs into SLNs is because some drugs have low solubility in water. Therefore, SLNs...

01 March 2021 3,703 3 View

Is there association of SARS-CoV-2 infection rate with meteorological factors?

There are contradictory research papers about the correlation between meteorological parameters and incidence of COVID-19 in some countries worldwide. Is there correlation between the...

15 February 2021 5,806 2 View

Why does the band sizes on Agarose gel electrophoresis differ from the peaks at capillary electrophoresis?

14 February 2021 4,773 4 View

How to calculate the Boiling point for metals at high vapor pressure?

In our experiment, some metal surfaces are exposed to radiation heat under high vapor gas pressure. I would like to ask if there is any way to calculate the boiling point for metals under high...

31 January 2021 249 4 View

What test should I use after a significant factoriual ANOVA?

Dear Colleagues Several resources recommended following significant interaction ANOVA with a simple main effect analysis to break down and interpret the interaction. I am wondering if I can...

29 December 2020 8,316 4 View

In your opinion , What is the percentage of demand for accountants and the percentage of stagnation ?

in your opinion , What is the percentage of demand for accountants and the percentage of stagnation ?

24 December 2020 5,349 3 View

How can increase the follower and citations of my articles?

I am looking for increasing the citations and reading my articles around the world.

13 December 2020 7,074 3 View

How to do energy optimization of charged molecule in gaussian?

when we want to study a reaction with a charged molecule (+) or (-) located on an atom, how do we optimize its structure with gaussian 09 thanks

29 September 2020 4,873 6 View

How can I do quantitive scoring for immunohistopathology(IHC)?

Is it enough inserting IHC image or quantitive details should be done, and how can I do this and what parameters needed ?

22 September 2020 1,881 2 View

Suggestion for the MS research topic?

hello everyone i have done work on NUMERICAL MODELING OF BRICK MASONRY in BSc. Now i want to carry the same/related work in MS too. i need your precious suggestions. Anyone having idea/topic...

14 September 2020 7,693 1 View

What could be the reason for not having further low chi square value (better agreement) in my refinement result?

I have tried every combination of parameter changes and after that i have a poor chi square value. I can't get it lower any further. I know there have been a lot of discussion about Rietveld...

26 February 2021 8,480 3 View

Why the CHi^2 is close to zero with a bad fitting but the Rp and Rwp are still high?

I am refining my XRD data using in FullProf program. The intensity of the modulated X-ray peaks is almost flat. I tried to adjust the peak intensities but unsuccessful. What is the reason? I guess...

23 February 2021 2,304 4 View

Why CHi^2 is reducing if I divide the intensity by a constant factor?

I was refining my XRD data in FullProf. Highest intensity was 400000. The fitting was good but still the Chi^2 value is very high (0.174E+04) I divided the intensity by some constant factor (say...

17 February 2021 3,383 5 View

How do I refine a specific region of my protein model so that it perfectly superposes with a template peptide PDB with the same sequence?

I have a protein model and want to replace a 12-amino acids-long region within the center of the model with those of a PDB file containing a 12-amino acids long peptide of the same sequence. This...

02 February 2021 779 2 View

Is it possible to do Reitveld Refinement on single crystal XRD data?

I tried to do single-crystal Rietveld Refinement on my single-crystal XRD data using the option "refinement on single-crystal data/ integrated intensity data" in Fullprof but it is giving error...

30 January 2021 7,813 3 View

How to take into account the high resolution of the x-ray difractometer?

At small angles or in case high collimation, the peaks become anisotropic and with a Lorentz addition. The resolution describes correctly only with adding Lorentz and anisatropy parameters. It...

26 January 2021 5,829 4 View

How much Ti and B (in ppm) is required for effective grain refinement and why?

To have the desired grain size in 6061 and 6063 Al alloy, what should be the minimum % of Ti and B pick up and what is the chemistry/metallurgy behind that?

07 January 2021 9,305 2 View

How to write a PHD proposal for a predefined research?

Hello everyone, I am aiming to write a PHD proposal of 1000 words. The research is described by the supervisor. That means, research questions, aim, and instruments are well defined by the...

01 January 2021 6,291 7 View

Rietveld refinement. Refined cell parameters are wrong?

I am trying to refine my XRD data with Fullprof software. Although I got low values for R Bragg and Chi 2 factors, when I insert new cell parameters as phase, they don't fit all peaks. In fact,...

18 December 2020 9,322 7 View

Modelling of proton disorder from SCXRD data?

Hi Is it possible to model a proton disorder from the single crystal X-ray diffraction data? We don't have access to neutron diffraction. #crystallography #SCXRD #refinement of structures Thanks

12 December 2020 9,507 3 View