Is there any data on Rhesus prophylaxis for women with weak or partial D types?
Which weak D types would be in danger of immunization, and how much Anti-D (dosage) should they get, as their red cells will surely react with the antibody?
What do you do?
Dear Niklas,
thank you very much for the profound answer - it supports my idea of the situation. I have read most of the publications you cited, but did not so far read the one by Gregory Denomme! Thanks for that one, very much appreciate it!
Hi Julian,
Although most guidelines recommend anti-D prophylaxis for all Rh(-) women who are pregnant, it's true that according to the current stand of knowledge, one should additionally test for D antigen variants (weak D) even if the immediate spin results D negative. To my knowledge if a woman tests D(-) at immediate spin but positive for D variants an anti-D prophylaxis is not recommended, since weak D can act like D(+) when it's the recipient blood and this can endanger the mother.
But it would certainly interest me as well if you run into more detailed information on this topic!
Best, Zeynep
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