Restriction nucleases often recognize palindromic DNA sequences

and often cut the recognition sequence asymmetrically. For example,

the restriction endonuclease EcoRI cleaves the sequence GGATCC

by breaking the bond connecting the two guanines in the recognition

sequence. What is meant by a palindromic DNA sequence, and

why does asymmetric cutting of a palindromic DNA sequence generate

fragments with ‘sticky ends’?

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