If we have a lowest published toxic dose value, is there any way by which we can estimate the Lethal dose 50 values from it?
LPTD is lowest dose which produces signs of toxicity....but not mortality. LD50 is dose produces mortality in 50% of tested animals.....
What does LD50 mean?
LD stands for "Lethal Dose". LD50 is the amount of a material, given all at once, which causes the death of 50% (one half) of a group of test animals. The LD50 is one way to measure the short-term poisoning potential (acute toxicity) of a material.
Toxicologists can use many kinds of animals but most often testing is done with rats and mice. It is usually expressed as the amount of chemical administered (e.g., milligrams) per 100 grams (for smaller animals) or per kilogram (for bigger test subjects) of the body weight of the test animal. The LD50 can be found for any route of entry or administration but dermal (applied to the skin) and oral (given by mouth) administration methods are the most common.
What does LC50 mean?
LC stands for "Lethal Concentration". LC values usually refer to the concentration of a chemical in air but in environmental studies it can also mean the concentration of a chemical in water.
According to the OECD (Organisation for Economic Cooperation and Development) Guidelines for the Testing of Chemicals, a traditional experiment involves groups of animals exposed to a concentration (or series of concentrations) for a set period of time (usually 4 hours). The animals are clinically observed for up to 14 days.
The concentrations of the chemical in air that kills 50% of the test animals during the observation period is the LC50 value. Other durations of exposure (versus the traditional 4 hours) may apply depending on specific laws.
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