which chromosome affected diabetes(chromosome 6 ?) or any other also. and also suggest me where i can get chromosomes list wise diseases and gene
Thankyou
Hi Suvarna
I'm sure in OMIM you'll be glad to see that diabetes genes or associated genes are all over the genome:
https://www.omim.org/search/advanced/geneMap
all the best
fred
As it is known, Type 1 Diabetes Mellitus(type1-DM) is a "complex trait" probably several but also possible that many genes are involved contributing autoimmunity which kills beta cells in the pancreas and IDDM-1(insulin dependent diabetes mellitus) according to the claims of physiologic researches, has at least one dibetogenic gene in chromosome 6 for type1-DM !?
Diabetogenic gene is in chromosome 6 and it's an HLA (human leukocyte antigen) complex...
https://dtc.ucsf.edu/types-of-diabetes/type1/understanding-type-1-diabetes/autoimmunity/genetics-of-type-1a/
don't forget type 2 diabetes and all its cousins as MODY...
you'll find monogenic forms of diabetes with implication sometimes of modifier genes, and polygenic forms too, but commonly multifactorial forms for which genetics and environment play a dual job.
fred
DM results from a combination of genetic and lifestyle factors, some of which have not been identified. Studies have identified at least 150 DNA variations that are associated with the risk of developing type 2 diabetes.
About 10 loci in the human genome have now been found that seem to confer susceptibility to Type 1 diabetes. Among these are 1) a gene at the locus IDDM2 on chromosome 11 and 2) the gene for glucokinase (GCK), an enzyme that is key to glucose metabolism which helps modulate insulin secretion, on chromosome 7.
The risk of developing type 1 diabetes is increased by certain variants of the HLA-DQA1, HLA-DQB1, and HLA-DRB1 genes. These genes provide instructions for making proteins that play a critical role in the immune system.
Chromosome 6 is functionally associated with more than 120 major human diseases, including cancer, heart disease, infectious, immune and inflammatory disorders and mental illnesses.
The insulin gene is located on the short arm of chromosome 11 in humans.